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[Simulation study of anti-hypoxia active fraction of Xiangdan injection by support vector machine].
- Source :
-
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials [Zhong Yao Cai] 2009 Aug; Vol. 32 (8), pp. 1285-7. - Publication Year :
- 2009
-
Abstract
- Objective: To investigate the anti-hypoxia active fraction of Xiangdan injection.<br />Methods: The anti-hypoxia experiment under normal pressure with mice was adopted on the basis of orthogonal design, and a support vector machine model was established for pharmacodynamics prediction of TCM prescriptions. Moreover, the anti-hypoxia active fraction of Xiangdan injection was determined by experimental confirmation.<br />Results: The prediction model established in this study could predict the drug actions of different formulas.<br />Conclusion: As indicated in model prediction and experimental confirmation, the pharmacodynamic actions of several formulas are superior to that of the original formula, and ADE has the best effect.
- Subjects :
- Animals
Drug Combinations
Drug Design
Drug Interactions
Drugs, Chinese Herbal administration & dosage
Female
Hypoxia mortality
Injections, Intraperitoneal
Male
Mice
Random Allocation
Rutaceae chemistry
Salvia miltiorrhiza chemistry
Solvents chemistry
Algorithms
Artificial Intelligence
Drugs, Chinese Herbal chemistry
Drugs, Chinese Herbal pharmacology
Hypoxia drug therapy
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1001-4454
- Volume :
- 32
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
- Publication Type :
- Academic Journal
- Accession number :
- 19960955