Back to Search
Start Over
Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors.
- Source :
-
Cancer cell [Cancer Cell] 2009 Dec 08; Vol. 16 (6), pp. 533-46. - Publication Year :
- 2009
-
Abstract
- We discovered a high-level amplicon involving the chr19q13.41 microRNA (miRNA) cluster (C19MC) in 11/45 ( approximately 25%) primary CNS-PNET, which results in striking overexpression of miR-517c and 520g. Constitutive expression of miR-517c or 520g promotes in vitro and in vivo oncogenicity, modulates cell survival, and robustly enhances growth of untransformed human neural stem cells (hNSCs) in part by upregulating WNT pathway signaling and restricting differentiation of hNSCs. Remarkably, the C19MC amplicon, which is very rare in other brain tumors (1/263), identifies an aggressive subgroup of CNS-PNET with distinct gene-expression profiles, characteristic histology, and dismal survival. Our data implicate miR-517c and 520g as oncogenes and promising biological markers for CNS-PNET and provide important insights into oncogenic properties of the C19MC locus.
- Subjects :
- Animals
Brain Neoplasms pathology
Cell Differentiation
Humans
Mice
Neuroectodermal Tumors, Primitive pathology
Signal Transduction
Stem Cells
Wnt Proteins metabolism
Brain Neoplasms genetics
Chromosomes, Human, Pair 19
Gene Amplification
MicroRNAs genetics
Neuroectodermal Tumors, Primitive genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1878-3686
- Volume :
- 16
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Cancer cell
- Publication Type :
- Academic Journal
- Accession number :
- 19962671
- Full Text :
- https://doi.org/10.1016/j.ccr.2009.10.025