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Sleep architecture and attenuated heart rate response to arousal from sleep in patients with autonomic failure.
- Source :
-
Sleep medicine [Sleep Med] 2010 Jan; Vol. 11 (1), pp. 87-92. Date of Electronic Publication: 2009 Dec 04. - Publication Year :
- 2010
-
Abstract
- Objective: To determine if patients with autonomic failure have increased sleep disturbances and if multiple system atrophy (MSA) and pure autonomic failure (PAF) patients have frequent arousals from sleep associated with an attenuated heart rate (HR) response compared to healthy volunteers.<br />Methods: With informed consent, 10 autonomic failure patients and 10 healthy volunteers were studied. Sleep disturbances were scored using standard criteria. Arousals were identified from stage 2 sleep and differences in the R-R interval between groups were tested using a mixed-model regression analysis.<br />Results: Three MSA and one PAF patient had obstructive sleep apnoea compared to one volunteer. One MSA and three PAF patients had periodic limb movements. One MSA patient had REM behaviour disorder. The autonomic patients had significantly reduced total sleep time (p=0.007) and sleep efficiency (p=0.003). The HR response to arousal was smaller in autonomic failure patients compared to volunteers during the early phase of the arousal (p=0.047), but not the later phase (p=0.67).<br />Conclusion: Autonomic failure patients have increased sleep disturbances compared to healthy volunteers. The smaller HR response in autonomic failure patients suggests that an intact sympathetic nervous system is a key component of the HR response associated with arousal from sleep.<br /> (Copyright 2009 Elsevier B.V. All rights reserved.)
- Subjects :
- Adult
Aged
Autonomic Nervous System physiopathology
Comorbidity
Female
Humans
Male
Middle Aged
Multiple System Atrophy diagnosis
Nocturnal Myoclonus Syndrome diagnosis
Nocturnal Myoclonus Syndrome physiopathology
Pure Autonomic Failure diagnosis
REM Sleep Behavior Disorder diagnosis
REM Sleep Behavior Disorder physiopathology
Reference Values
Sleep Apnea, Obstructive diagnosis
Sleep Apnea, Obstructive physiopathology
Sleep Stages physiology
Sleep Wake Disorders diagnosis
Arousal physiology
Heart Rate physiology
Multiple System Atrophy physiopathology
Polysomnography
Pure Autonomic Failure physiopathology
Sleep Wake Disorders physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1878-5506
- Volume :
- 11
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Sleep medicine
- Publication Type :
- Academic Journal
- Accession number :
- 19962940
- Full Text :
- https://doi.org/10.1016/j.sleep.2008.12.017