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[A case of 5-fluorouracil-induced hyperammmonia after chemotherapy for metastatic colon cancer].
- Source :
-
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology [Nihon Shokakibyo Gakkai Zasshi] 2009 Dec; Vol. 106 (12), pp. 1744-50. - Publication Year :
- 2009
-
Abstract
- A 79-year-old woman with colon cancer and multiple liver metastases was admitted to our hospital for systemic chemotherapy. She underwent first cycle of modified FOLFOX6 chemotherapy. She was confused on treatment day 5. Blood test revealed her serum ammonia level to be 121 microg/dl. We diagnosed 5-fluorouracil (5FU)-induced hyperammonemia. Conservative treatment resulted in improvement of metal status. The reason for hyperammonemia after administration of 5FU was the excess production of ammonium from metabolites of 5FU.
- Subjects :
- Aged
Antimetabolites, Antineoplastic administration & dosage
Antineoplastic Combined Chemotherapy Protocols adverse effects
Female
Fluorouracil administration & dosage
Humans
Leucovorin adverse effects
Liver Neoplasms secondary
Organoplatinum Compounds adverse effects
Antimetabolites, Antineoplastic adverse effects
Colonic Neoplasms drug therapy
Fluorouracil adverse effects
Hyperammonemia chemically induced
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0446-6586
- Volume :
- 106
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
- Publication Type :
- Academic Journal
- Accession number :
- 19966516