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A comparison of dose-response models for the parotid gland in a large group of head-and-neck cancer patients.
- Source :
-
International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 2010 Mar 15; Vol. 76 (4), pp. 1259-65. Date of Electronic Publication: 2009 Dec 16. - Publication Year :
- 2010
-
Abstract
- Purpose: The dose-response relationship of the parotid gland has been described most frequently using the Lyman-Kutcher-Burman model. However, various other normal tissue complication probability (NTCP) models exist. We evaluated in a large group of patients the value of six NTCP models that describe the parotid gland dose response 1 year after radiotherapy.<br />Methods and Materials: A total of 347 patients with head-and-neck tumors were included in this prospective parotid gland dose-response study. The patients were treated with either conventional radiotherapy or intensity-modulated radiotherapy. Dose-volume histograms for the parotid glands were derived from three-dimensional dose calculations using computed tomography scans. Stimulated salivary flow rates were measured before and 1 year after radiotherapy. A threshold of 25% of the pretreatment flow rate was used to define a complication. The evaluated models included the Lyman-Kutcher-Burman model, the mean dose model, the relative seriality model, the critical volume model, the parallel functional subunit model, and the dose-threshold model. The goodness of fit (GOF) was determined by the deviance and a Monte Carlo hypothesis test. Ranking of the models was based on Akaike's information criterion (AIC).<br />Results: None of the models was rejected based on the evaluation of the GOF. The mean dose model was ranked as the best model based on the AIC. The TD(50) in these models was approximately 39 Gy.<br />Conclusions: The mean dose model was preferred for describing the dose-response relationship of the parotid gland.<br /> (Copyright 2010 Elsevier Inc. All rights reserved.)
- Subjects :
- Dose-Response Relationship, Radiation
Humans
Parotid Gland metabolism
Prospective Studies
Radiotherapy, Intensity-Modulated adverse effects
Radiotherapy, Intensity-Modulated methods
Relative Biological Effectiveness
Time Factors
Xerostomia etiology
Head and Neck Neoplasms radiotherapy
Models, Statistical
Parotid Gland radiation effects
Radiation Injuries complications
Saliva metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1879-355X
- Volume :
- 76
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- International journal of radiation oncology, biology, physics
- Publication Type :
- Academic Journal
- Accession number :
- 20005639
- Full Text :
- https://doi.org/10.1016/j.ijrobp.2009.07.1685