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[Differences in cerebral blood flow following risperidone treatment in children with autistic disorder].
- Source :
-
Turk psikiyatri dergisi = Turkish journal of psychiatry [Turk Psikiyatri Derg] 2009 Winter; Vol. 20 (4), pp. 346-56. - Publication Year :
- 2009
-
Abstract
- Objective: Functional changes in the brains of autistic children due to risperidone treatment and theirs relationship to the symptom clusters are yet unknown. In this autistic disorder case series we aimed to comparatively evaluate the clinical findings before and after risperidone treatment, and regional cerebral blood flow (rCBF) findings with 99mTc-hexamethylpropyleneamine oxime (HMPAO) brain SPECT.<br />Method: Eleven autistic patients (age range: 6-7 years; 4 girls, 7 boys) received risperidone therapy (1.5-2.5 mg d(-1)) and were followed-up for 3 months. All the patients underwent neurologic examinations, psychometric examinations, and SPECT imaging, both at the start of risperidone treatment and 3 months after the treatment started. Clinical observations, and the observations of parents and teachers were recorded. These results were compared with cerebral perfusion indices obtained from SPECT data.<br />Results: After 3 months of treatment changes in rCBF were observed in various regions and to varying degrees. We observed relationships between clinical symptoms and pre-therapy rCBF findings, and between clinical improvement and rCBF changes.<br />Conclusion: Findings in the present case series are the first to demonstrate a relationship between clinical improvement and regional perfusion patterns after risperidone treatment. We think that these findings may contribute to the understanding of the neurofunctional mechanisms and hypothetical models of autism.
- Subjects :
- Antipsychotic Agents therapeutic use
Autistic Disorder diagnostic imaging
Cerebrovascular Circulation drug effects
Cerebrovascular Circulation radiation effects
Child
Corpus Callosum blood supply
Female
Follow-Up Studies
Humans
Male
Regional Blood Flow drug effects
Regional Blood Flow physiology
Regional Blood Flow radiation effects
Technetium Tc 99m Exametazime
Tomography, Emission-Computed, Single-Photon
Autistic Disorder drug therapy
Autistic Disorder physiopathology
Cerebrovascular Circulation physiology
Risperidone therapeutic use
Subjects
Details
- Language :
- Turkish
- ISSN :
- 1300-2163
- Volume :
- 20
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Turk psikiyatri dergisi = Turkish journal of psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 20013426