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Differential tissue distribution of sesaminol triglucoside and its metabolites in rats fed with lignan glycosides from sesame meal with or without nano/submicrosizing.
- Source :
-
Journal of agricultural and food chemistry [J Agric Food Chem] 2010 Jan 13; Vol. 58 (1), pp. 563-9. - Publication Year :
- 2010
-
Abstract
- Lignan glycosides are important functional compounds in sesame meal. In the present study, we investigated whether the tissue distribution of nano/submicrosized lignan glycosides from sesame meal (N-LGSM) differs from lignan glycosides from sesame meal (LGSM). LGSM was nano/submicrosized with 0.3 mm zirconia beads as the milling media. The average particle size of the 4% LGSM aqueous suspension reduced rapidly from approximately 2 microm to 200 nm after media milling at an agitation speed of 3600 rpm for 30 min. We examined the tissue distribution of sesaminol triglucoside (ST), the main component in LGSM, in Sprague-Dawley (SD) rats. The concentrations of ST were determined in various tissues and plasma within a 24 h period after oral administration of N-LGSM and LGSM (800 mg/kg of body weight). The results showed that higher concentrations of ST and its metabolites (sesaminol, sesaminol sulfate, and sesaminol glucuronide) were found in N-LGSM compared to those in LGSM in most tissues, especially liver and small intestine. Sesaminol glucuronide was the main metabolite in rats. After 3 h of oral administration, around 70% higher concentration of sesaminol glucuronide was found in N-LGSM compared to that in LGSM. This study clearly showed that LGSM is more bioavailable after nano/submicrosizing.
- Subjects :
- Animals
Food Handling
Glucosides administration & dosage
Glucosides metabolism
Glycosides chemistry
Glycosides metabolism
Lignans chemistry
Lignans metabolism
Particle Size
Plant Preparations chemistry
Plant Preparations metabolism
Rats
Rats, Sprague-Dawley
Sesamum metabolism
Tissue Distribution
Glucosides pharmacokinetics
Glycosides administration & dosage
Lignans administration & dosage
Plant Preparations administration & dosage
Sesamum chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1520-5118
- Volume :
- 58
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of agricultural and food chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 20014846
- Full Text :
- https://doi.org/10.1021/jf9028046