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Ligand-controlled enantioselective [2 + 2] cycloaddition of oxabicyclic alkenes with terminal alkynes using chiral iridium catalysts.
- Source :
-
Organic letters [Org Lett] 2010 Jan 15; Vol. 12 (2), pp. 304-6. - Publication Year :
- 2010
-
Abstract
- The first catalytic asymmetric [2 + 2] cycloaddition of oxabicyclic alkenes and terminal alkynes has been developed. This iridium-catalyzed enantioselective [2 + 2] cycloaddition allows the formation of four stereocenters in a single step with excellent enantioselectivity (94-->99% ee).
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 12
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 20025256
- Full Text :
- https://doi.org/10.1021/ol902574c