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Caenorhabditis elegans proteomics comes of age.
- Source :
-
Proteomics [Proteomics] 2010 Feb; Vol. 10 (4), pp. 846-57. - Publication Year :
- 2010
-
Abstract
- Caenorhabditis elegans, a free-living soil nematode, is an ideal model system for studying various physiological problems relevant to human diseases. Despite its short history, C. elegans proteomics is receiving great attention in multiple research areas, including the genome annotation, major signaling pathways (e.g. TGF-beta and insulin/IGF-1 signaling), verification of RNA interference-mediated gene targeting, aging, disease models, as well as peptidomic analysis of neuropeptides involved in behavior and locomotion. For example, a proteome-wide profiling of developmental and aging processes not only provides basic information necessary for constructing a molecular network, but also identifies important target proteins for chemical modulation. Although C. elegans has a simple body system and neural circuitry, it exhibits very complicated functions ranging from feeding to locomotion. Investigation of these functions through proteomic analysis of various C. elegans neuropeptides, some of which are not found in the predicted genome sequence, would open a new field of peptidomics. Given the importance of nematode infection in plants and mammalian pathogenesis pathways, proteomics could be applied to investigate the molecular mechanisms underlying plant- or animal-nematode pathogenesis and to identify novel antinematodal drugs. Thus, C. elegans proteomics, in combination of other molecular, biological and genetic techniques, would provide a versatile new tool box for the systematic analysis of gene functions throughout the entire life cycle of this nematode.
- Subjects :
- Animals
Antinematodal Agents
Caenorhabditis elegans pathogenicity
Genome, Helminth physiology
Humans
Models, Biological
Nematode Infections drug therapy
Nematode Infections metabolism
Nematode Infections parasitology
Peptides genetics
Peptides metabolism
Proteome analysis
Proteome chemistry
Proteome genetics
Caenorhabditis elegans physiology
Caenorhabditis elegans Proteins physiology
Proteomics methods
Subjects
Details
- Language :
- English
- ISSN :
- 1615-9861
- Volume :
- 10
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Proteomics
- Publication Type :
- Academic Journal
- Accession number :
- 20029841
- Full Text :
- https://doi.org/10.1002/pmic.200900542