Back to Search
Start Over
Therapy failure following selection of enfuvirtide-resistant HIV-1 in cerebrospinal fluid.
- Source :
-
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2010 Feb 01; Vol. 50 (3), pp. 387-90. - Publication Year :
- 2010
-
Abstract
- We report the selection of enfuvirtide-resistant human immunodeficiency virus type 1 in cerebrospinal fluid, resulting in subsequent loss of viral suppression in the plasma. This case report emphasizes the potential danger of low-level penetration of entry inhibitors into the central nervous system.
- Subjects :
- Anti-HIV Agents therapeutic use
Enfuvirtide
HIV Envelope Protein gp41 therapeutic use
HIV Infections virology
HIV-1 isolation & purification
Humans
Male
Middle Aged
Peptide Fragments therapeutic use
Selection, Genetic
Treatment Failure
Anti-HIV Agents pharmacology
Cerebrospinal Fluid virology
Drug Resistance, Viral
HIV Envelope Protein gp41 pharmacology
HIV Infections drug therapy
HIV-1 drug effects
Peptide Fragments pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6591
- Volume :
- 50
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
- Publication Type :
- Academic Journal
- Accession number :
- 20047481
- Full Text :
- https://doi.org/10.1086/649874