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Identification of potential and selective collagenase, gelatinase inhibitors from Crataegus pinnatifida.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Feb 01; Vol. 20 (3), pp. 991-3. Date of Electronic Publication: 2009 Dec 22. - Publication Year :
- 2010
-
Abstract
- Four oligomeric procyanidins were isolated from the MeOH extracts of the leaves of Crataegus pinnatifida (Rosaceae). Investigation of collagenase and gelatinase inhibitory natural components afforded four oligomeric procyanidins. Of these, 2 and 3 exhibited collagenase inhibitory activity (IC(50)) at a concentration of less than 1 microM, and 3 showed gelatinases A and B inhibitory activity (IC(50)) at 0.4 and 2.3 microM, respectively.<br /> (Copyright (c) 2009 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 20
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 20053563
- Full Text :
- https://doi.org/10.1016/j.bmcl.2009.12.059