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Parotid gland function after radiotherapy: the combined michigan and utrecht experience.
- Source :
-
International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 2010 Oct 01; Vol. 78 (2), pp. 449-53. Date of Electronic Publication: 2010 Jan 07. - Publication Year :
- 2010
-
Abstract
- Purpose: To analyze the combined and updated results from the University of Michigan and University Medical Center Utrecht on normal tissue complication probability (NTCP) of the parotid gland 1 year after radiotherapy (RT) for head-and-neck (HN) cancer.<br />Patients and Methods: A total of 222 prospectively analyzed patients with various HN malignancies were treated with conventional and intensity-modulated RT. Stimulated individual parotid gland flow rates were measured before RT and 1 year after RT using Lashley cups at both centers. A flow ratio <25% of pretreatment was defined as a complication. The data were fitted to the Lyman-Kutcher-Burman model.<br />Results: A total of 384 parotid glands (Michigan: 157; Utrecht: 227 glands) was available for analysis 1 year after RT. Combined NTCP analysis based on mean dose resulted in a TD(50) (uniform dose leading to 50% complication probability) of 39.9 Gy and m (steepness of the curve) of 0.40. The resulting NTCP curve had good qualitative agreement with the combined clinical data. Mean doses of 25-30 Gy were associated with 17-26% NTCP.<br />Conclusions: A definite NTCP curve for parotid gland function 1 year after RT is presented, based on mean dose. No threshold dose was observed, and TD(50) was equal to 40 Gy.<br /> (2010 Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Dose-Response Relationship, Radiation
Female
Humans
Lethal Dose 50
Likelihood Functions
Male
Michigan
Middle Aged
Models, Biological
Netherlands
Parotid Gland physiopathology
Prospective Studies
Radiotherapy, Intensity-Modulated methods
Salivation physiology
Time Factors
Xerostomia etiology
Young Adult
Head and Neck Neoplasms radiotherapy
Parotid Gland radiation effects
Radiotherapy, Intensity-Modulated adverse effects
Salivation radiation effects
Subjects
Details
- Language :
- English
- ISSN :
- 1879-355X
- Volume :
- 78
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- International journal of radiation oncology, biology, physics
- Publication Type :
- Academic Journal
- Accession number :
- 20056347
- Full Text :
- https://doi.org/10.1016/j.ijrobp.2009.07.1708