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Newcastle disease virus as an oncolytic agent.

Authors :
Ravindra PV
Tiwari AK
Sharma B
Chauhan RS
Source :
The Indian journal of medical research [Indian J Med Res] 2009 Nov; Vol. 130 (5), pp. 507-13.
Publication Year :
2009

Abstract

Cancer is a major cause of deaths in humans. Though there has been significant progress in cancer therapy, the limited efficacy and toxicities of current chemo- and radiotherapies have provided an impetus for the search of new therapeutics. A therapeutic approach, which uses viruses for the treatment of cancer termed, oncolytic virotherapy has recently emerged. Newcastle disease virus (NDV) is one such virus with an inherent oncolytic property. NDV causes a highly infectious disease in poultry worldwide. In humans it is reported to have oncolytic and immuno-stimulatory effects. It specifically replicates in tumour cells while sparing normal cells and cause oncolysis. For many years different strains of the NDV have been investigated for treatment of various human cancers. Recent advances in reverse genetics provided investigators the tools to produce recombinant NDV with improved oncolytic property.

Details

Language :
English
ISSN :
0971-5916
Volume :
130
Issue :
5
Database :
MEDLINE
Journal :
The Indian journal of medical research
Publication Type :
Academic Journal
Accession number :
20090097