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Proliferative activity and diagnostic delay in oral cancer.
- Source :
-
Head & neck [Head Neck] 2010 Oct; Vol. 32 (10), pp. 1377-84. - Publication Year :
- 2010
-
Abstract
- Background: Tumor stage may relate to the chronology of neoplasm growth and has been used as an outcome variable when studying diagnostic delay in oral cancer. However, tumor growth rate may act as a confounding factor.<br />Methods: We reviewed a total of 63 incident cases of oral cancer. The variables considered for the study included age, sex, smoking history, tumor site, TNM stage, Ki-67 score, and diagnostic delay.<br />Results: Significant differences between survivors and exitus were found in terms of tumor stage at diagnosis (I-II vs III-IV), sex, and Ki-67 scores. When the analysis was adjusted for tumor stage at diagnosis (I-II vs III-IV), proliferative activity resulted to be an independent prognostic factor for survival, whereas diagnostic delay did not influence survival.<br />Conclusion: These results seem to suggest that survival from oral cancer is affected more by the biology of the cancer (rapid tumor growth) than by diagnostic delay.<br /> (© 2010 Wiley Periodicals, Inc.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell metabolism
Cell Proliferation
Female
Humans
Ki-67 Antigen metabolism
Male
Middle Aged
Mouth Neoplasms metabolism
Prognosis
Retrospective Studies
Carcinoma, Squamous Cell mortality
Carcinoma, Squamous Cell pathology
Delayed Diagnosis
Mouth Neoplasms mortality
Mouth Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0347
- Volume :
- 32
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Head & neck
- Publication Type :
- Academic Journal
- Accession number :
- 20091693
- Full Text :
- https://doi.org/10.1002/hed.21338