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The drug-naïve OCD patients imaging genetics, cognitive and treatment response study: methods and sample description.
- Source :
-
Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) [Braz J Psychiatry] 2009 Dec; Vol. 31 (4), pp. 349-53. - Publication Year :
- 2009
-
Abstract
- Objective: To describe a protocol that was based on an integrative neurobiological model of scientific investigation to better understand the pathophysiology of obsessive-compulsive disorder and to present the clinical and demographic characteristics of the sample.<br />Method: A standardized research protocol that combines different methods of investigation (genetics, neuropsychology, morphometric magnetic resonance imaging and molecular neuroimaging of the dopamine transporter) obtained before and after treatment of drug-naïve adult obsessive-compulsive disorder patients submitted to a sequentially allocated 12-week clinical trial with a selective serotonin reuptake inhibitor (fluoxetine) and group cognitive-behavioral therapy.<br />Results: Fifty-two treatment-naïve obsessive-compulsive disorder patients entered the clinical trial (27 received fluoxetine and 25 received group cognitive-behavioral therapy). At baseline, 47 blood samples for genetic studies, 50 neuropsychological evaluations, 50 morphometrical magnetic resonance images and 48 TRODAT-1 single-photon emission computed tomography (SPECT) exams were obtained. After 12 weeks, 38 patients completed the protocol (fluoxetine = 20 and GCBT = 18). Thirty-eight neuropsychological evaluations, 31 morphometrical magnetic resonance images and 34 TRODAT-1 SPECT exams were obtained post-treatment. Forty-one healthy controls matched for age, gender, socioeconomic status, level of education and laterality were submitted to the same research procedures at baseline.<br />Conclusion: The comprehensive treatment response protocol applied in this project allowing integration on genetic, neuropsychological, morphometrical and molecular imaging of the dopamine transporter data in drug-naïve patients has the potential to generate important original information on the neurobiology of obsessive-compulsive disorder, and at the same time be clinically meaningful.
- Subjects :
- Adolescent
Adult
Aged
Humans
Magnetic Resonance Imaging
Middle Aged
Molecular Imaging
Obsessive-Compulsive Disorder physiopathology
Tomography, Emission-Computed, Single-Photon
Treatment Outcome
Young Adult
Cognitive Behavioral Therapy
Fluoxetine therapeutic use
Obsessive-Compulsive Disorder therapy
Selective Serotonin Reuptake Inhibitors therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1809-452X
- Volume :
- 31
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
- Publication Type :
- Academic Journal
- Accession number :
- 20098825
- Full Text :
- https://doi.org/10.1590/s1516-44462009000400011