Accumulation of advanced glycation end products in canine atherosclerosis.

Authors :: Chiers K
Vandenberge V
Ducatelle R
Source :: Journal of comparative pathology [J Comp Pathol] 2010 Jul; Vol. 143 (1), pp. 65-9. Date of Electronic Publication: 2010 Jan 29.
Publication Year :: 2010
Abstract: Atherosclerosis is an uncommon lesion in animals and particularly in dogs. Prominent atherosclerotic lesions of the coronary arteries are described in three dogs. These comprised an expansion of the tunica media by the accumulation of foam cells and/or cholesterol crystals, with subsequent narrowing of the vascular lumen. Immunohistochemical analysis revealed the accumulation of advanced glycation end products (AGEs) in foam cells, macrophages and lymphocytes. As in man, these findings suggest a possible role of AGEs in the development of canine atherosclerosis.<br /> ((c) 2009 Elsevier Ltd. All rights reserved.)