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YC-1 enhances natural killer cell differentiation from hematopoietic stem cells.
- Source :
-
International immunopharmacology [Int Immunopharmacol] 2010 Apr; Vol. 10 (4), pp. 481-6. Date of Electronic Publication: 2010 Jan 29. - Publication Year :
- 2010
-
Abstract
- NK cells play crucial roles in innate immunity and adaptive immunity. The detailed mechanisms, however, governing NK cell development remains unclear. In this study, we report that YC-1 significantly enhances NK cell populations differentiated from human umbilical cord blood hematopoietic stem cells (HSCs). NK cells increased by YC-1 display both phenotypic and functional features of fully mature NK (mNK) cells, but YC-1 does not affect the activation of mNK cells. YC-1 did not affect cGMP production and phosphorylation of STAT-5 which is essential for IL-15R signaling. On the other hand, YC-1 increased p38 MAPK phosphorylation during NK cell differentiation. Furthermore, p38 inhibitor SB203580 inhibited the differentiation of NK cells enhanced by YC-1. Taken together, these data suggest that YC-1 enhances NK cell differentiation through the activation of p38 MAPK which is involved in NK cell differentiation.<br /> (Copyright 2010 Elsevier B.V. All rights reserved.)
- Subjects :
- Blotting, Western
Cell Line, Tumor
Cyclic GMP metabolism
Enzyme Inhibitors pharmacology
Fetal Blood cytology
Flow Cytometry
Humans
Imidazoles pharmacology
Indazoles antagonists & inhibitors
Phosphorylation
Pyridines pharmacology
Receptors, Interleukin-15 drug effects
STAT5 Transcription Factor biosynthesis
Signal Transduction drug effects
p38 Mitogen-Activated Protein Kinases antagonists & inhibitors
p38 Mitogen-Activated Protein Kinases metabolism
Cell Differentiation drug effects
Enzyme Activators pharmacology
Hematopoietic Stem Cells drug effects
Indazoles pharmacology
Killer Cells, Natural drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1878-1705
- Volume :
- 10
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- International immunopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 20116458
- Full Text :
- https://doi.org/10.1016/j.intimp.2010.01.009