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Cadmium activates Arabidopsis MPK3 and MPK6 via accumulation of reactive oxygen species.
- Source :
-
Phytochemistry [Phytochemistry] 2010 Apr; Vol. 71 (5-6), pp. 614-8. Date of Electronic Publication: 2010 Jan 29. - Publication Year :
- 2010
-
Abstract
- Cadmium (Cd) is a non-essential toxic heavy metal that influences normal growth and development of plants. However, the molecular mechanisms by which plants recognize and respond to Cd remain poorly understood. We show that, in Arabidopsis, Cd activates the mitogen-activated protein kinases, MPK3 and MPK6, in a dose-dependent manner. Following treatment with Cd, these two MAPKs exhibited much higher activity in the roots than in the leaves, and pre-treatment with the reactive oxygen species (ROS) scavenger, glutathione, effectively inhibited their activation. These results suggest that the Cd sensing signaling pathway uses a build-up of ROS to trigger activation of Arabidopsis MPK3 and MPK6.<br /> (Copyright 2010 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adaptation, Physiological genetics
Arabidopsis metabolism
Arabidopsis Proteins genetics
Dose-Response Relationship, Drug
Gene Expression Regulation, Plant
Glutathione
Mitogen-Activated Protein Kinase Kinases genetics
Mitogen-Activated Protein Kinases genetics
Mutation
Plant Leaves metabolism
Plant Roots metabolism
Reverse Transcriptase Polymerase Chain Reaction
Arabidopsis enzymology
Arabidopsis Proteins metabolism
Cadmium toxicity
Mitogen-Activated Protein Kinase Kinases metabolism
Mitogen-Activated Protein Kinases metabolism
Oxidative Stress genetics
Reactive Oxygen Species metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3700
- Volume :
- 71
- Issue :
- 5-6
- Database :
- MEDLINE
- Journal :
- Phytochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 20116811
- Full Text :
- https://doi.org/10.1016/j.phytochem.2010.01.005