Back to Search
Start Over
[Recent development in animal testing to predict the skin and respiratory sensitizing potential of chemicals].
- Source :
-
Nihon eiseigaku zasshi. Japanese journal of hygiene [Nihon Eiseigaku Zasshi] 2010 Jan; Vol. 65 (1), pp. 14-9. - Publication Year :
- 2010
-
Abstract
- The identification of chemicals with skin and/or respiratory sensitizing potential is important for the prevention of allergic diseases in both living and work environments. Although a number of animal models for respiratory allergic diseases have been reported, none of these models meets the goals of broad assessments of chemical sensitizing potential. We are attempting to develop a test for predicting the respiratory sensitization of chemicals. In the evaluation of skin sensitization of chemicals, the mostly used predictive tests are the guinea pig maximization test, Buehler test, and mouse local lymph node assay (LLNA). However, only LLNA has been validated formally and independently. Recent studies have revealed that EC3 estimated by LLNA correlates well with human skin sensitizing potency and the threshold for the induction of skin sensitization in the human repeat patch test. Thus, LLNA can predict the potency of skin sensitizing potential of a chemical and its risk in humans.
- Subjects :
- Animals
Guinea Pigs
Humans
Hypersensitivity prevention & control
Local Lymph Node Assay
Mice
Predictive Value of Tests
Risk Assessment methods
Thymidine adverse effects
Thymidine analogs & derivatives
Thymidine immunology
Toluene 2,4-Diisocyanate adverse effects
Toluene 2,4-Diisocyanate immunology
Animal Experimentation
Bronchial Provocation Tests methods
Patch Tests methods
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0021-5082
- Volume :
- 65
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nihon eiseigaku zasshi. Japanese journal of hygiene
- Publication Type :
- Academic Journal
- Accession number :
- 20134104
- Full Text :
- https://doi.org/10.1265/jjh.65.14