Back to Search
Start Over
Homogentisic acid interference in routine urine creatinine determination.
Homogentisic acid interference in routine urine creatinine determination.
- Source :
-
Molecular genetics and metabolism [Mol Genet Metab] 2010 May; Vol. 100 (1), pp. 103-4. Date of Electronic Publication: 2010 Jan 21. - Publication Year :
- 2010
-
Abstract
- We report the artifactual elevation of homogentisic acid (HGA) in urine from alkaptonuric patients after replacing the creatinine method (Jaffe reaction) in our laboratory with an automated enzymatic method. Samples with elevated HGA by GC-MS had lower creatinine values as determined by the enzymatic method than by the Jaffe reaction. The low creatinine values were due to interference by HGA in the enzymatic method. The enzymatic method is unsuitable for creatinine determination in urine of patients with alkaptonuria.<br /> ((c) 2010 Elsevier Inc. All rights reserved.)
- Subjects :
- Alkaptonuria urine
Artifacts
Humans
Creatinine urine
Homogentisic Acid urine
Subjects
Details
- Language :
- English
- ISSN :
- 1096-7206
- Volume :
- 100
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Molecular genetics and metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 20138792
- Full Text :
- https://doi.org/10.1016/j.ymgme.2010.01.006