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Spatial memory deficits and thalamic serotonergic metabolite change in thiamine deficient rats.
- Source :
-
Behavioural brain research [Behav Brain Res] 2010 Jun 26; Vol. 210 (1), pp. 140-2. Date of Electronic Publication: 2010 Feb 12. - Publication Year :
- 2010
-
Abstract
- The purposes of the present study were to verify the effects of a severe thiamine deficiency episode on spatial cognitive aspects and thalamic serotonergic parameters. The animals were submitted to a severe thiamine deficiency treatment that was interrupted after the onset of the last neurological signs. The results obtained confirm previous findings about TD deficiency effects on cognitive function and, further show that this vitamin increases the thalamic serotonine metabolite, 5-hidroxyindolacetic acid (5-HIAA), level. In addition, the present data shed light on the importance of this metabolite in spatial cognitive function.
- Subjects :
- Analysis of Variance
Animals
Male
Maze Learning physiology
Memory Disorders etiology
Neuropsychological Tests
Pyrithiamine
Rats
Rats, Wistar
Thiamine Deficiency chemically induced
Thiamine Deficiency complications
Time Factors
Hydroxyindoleacetic Acid metabolism
Memory Disorders metabolism
Serotonin metabolism
Space Perception physiology
Thalamus metabolism
Thiamine Deficiency metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7549
- Volume :
- 210
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Behavioural brain research
- Publication Type :
- Academic Journal
- Accession number :
- 20153779
- Full Text :
- https://doi.org/10.1016/j.bbr.2010.02.019