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A randomized study of the efficacy and safety of injectable poly-L-lactic acid versus human-based collagen implant in the treatment of nasolabial fold wrinkles.
- Source :
-
Journal of the American Academy of Dermatology [J Am Acad Dermatol] 2010 Mar; Vol. 62 (3), pp. 448-62. - Publication Year :
- 2010
-
Abstract
- Background: Injectable poly-L-lactic acid (PLLA) is a synthetic, biodegradable, biocompatible polymer device.<br />Objective: We sought to compare the efficacy and safety of injectable PLLA with human-derived collagen in treating nasolabial fold wrinkles.<br />Methods: In this randomized, evaluator-blinded, parallel-group, multicenter study, subjects received injectable PLLA (n = 116) or collagen (n = 117) injections (1-4 visits, 3-week intervals). Wrinkle Assessment Scale scores were calculated at screening; posttreatment week 3; months 3, 6, 9, and 13 (injectable PLLA or collagen groups); and months 19 and 25 (injectable PLLA group). Safety data were obtained from subject interviews and case report forms.<br />Results: Injectable PLLA significantly improved mean Wrinkle Assessment Scale scores (all time points, P < .001). Improvements (up to 25 months after last treatment) were significantly greater (P < .001) than with collagen for posttreatment months 3 to 13.<br />Limitations: Mostly white women and subjects with Fitzpatrick skin types II and III were included.<br />Conclusion: Injectable PLLA provides well-tolerated, effective, and long-lasting (up to 25 months) nasolabial fold wrinkle correction.<br /> (Copyright 2009 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1097-6787
- Volume :
- 62
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of the American Academy of Dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 20159311
- Full Text :
- https://doi.org/10.1016/j.jaad.2009.07.040