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Effects of human T-cell leukemia virus type 1 (HTLV-1) p13 on mitochondrial K+ permeability: A new member of the viroporin family?
- Source :
-
FEBS letters [FEBS Lett] 2010 May 17; Vol. 584 (10), pp. 2070-5. Date of Electronic Publication: 2010 Feb 17. - Publication Year :
- 2010
-
Abstract
- Human T-cell leukemia virus type-1 (HTLV-1) encodes a mitochondrial protein named p13. p13 mediates an inward K(+) current in isolated mitochondria that leads to mitochondrial swelling, depolarization, increased respiratory chain activity and reactive oxygen species (ROS) production. These effects trigger the opening of the permeability transition pore and are dependent on the presence of K(+) and on the amphipathic alpha helical domain of p13. In the context of cells, p13 acts as a sensitizer to selected apoptotic stimuli. Although it is not known whether p13 influences the activity of endogenous K(+) channels or forms a channel itself, it shares some structural and functional analogies with viroporins, a class of small integral membrane proteins that form pores and alter membrane permeability.<br /> (Copyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Amino Acid Sequence
Animals
Cell Transformation, Viral drug effects
Humans
Molecular Sequence Data
Permeability drug effects
Retroviridae Proteins chemistry
Retroviridae Proteins metabolism
Human T-lymphotropic virus 1
Mitochondria drug effects
Mitochondria metabolism
Potassium metabolism
Retroviridae Proteins pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3468
- Volume :
- 584
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- FEBS letters
- Publication Type :
- Academic Journal
- Accession number :
- 20170654
- Full Text :
- https://doi.org/10.1016/j.febslet.2010.02.030