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Positron emission tomography imaging of DMBA/TPA mouse skin multi-step tumorigenesis.

Authors :
Ishikawa TO
Kumar IP
Machado HB
Wong KP
Kusewitt D
Huang SC
Fischer SM
Herschman HR
Source :
Molecular oncology [Mol Oncol] 2010 Apr; Vol. 4 (2), pp. 119-25. Date of Electronic Publication: 2010 Feb 02.
Publication Year :
2010

Abstract

Many tumor cells have elevated rates of glucose uptake that can be measured quantitatively, noninvasively and repeatedly by positron emission tomography (PET) with 2-deoxy-2-[(18)F]-fluoro-D-glucose ((18)F-FDG). Clinical imaging with (18)F-FDG PET has been used for detection and staging of primary and metastatic tumors. High-resolution microPET scanning and murine cancer models make it possible to analyze longitudinally glucose metabolism during the appearance, development and progression of individual experimental tumors. In this study, we used (18)F-FDG microPET and micro computerized tomography (microCT) to investigate glucose uptake in the DMBA/TPA chemically-induced multistage mouse skin carcinogenesis model. (18)F-FDG uptake is significantly higher in all papillomas than in surrounding skin. Elevated (18)F-FDG uptake is observed when tumors can be identified morphologically, but not before. Although (18)F-FDG uptake is high in all fully invasive, malignant skin squamous cell carcinomas, uptake in papillomas and microinvasive malignant squamous cell carcinomas is variable and does not exhibit any correlation with tumor stage.<br /> (Copyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1878-0261
Volume :
4
Issue :
2
Database :
MEDLINE
Journal :
Molecular oncology
Publication Type :
Academic Journal
Accession number :
20171942
Full Text :
https://doi.org/10.1016/j.molonc.2010.01.005