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Diffuse alveolar hemorrhage following itraconazole injection.

Authors :
Izumikawa K
Nakano K
Kurihara S
Imamura Y
Yamamoto K
Miyazaki T
Sakamoto N
Seki M
Ishimatsu Y
Kakeya H
Yamamoto Y
Yanagihara K
Tsuchiya T
Yamasaki N
Tagawa T
Mukae H
Nagayasu T
Kohno S
Source :
Internal medicine (Tokyo, Japan) [Intern Med] 2010; Vol. 49 (5), pp. 497-500. Date of Electronic Publication: 2010 Mar 01.
Publication Year :
2010

Abstract

Diffuse alveolar hemorrhage (DAH) syndrome is potentially fatal. We encountered a nearly fatal case of DAH possibly due to intravenous itraconazole (ITCZ). A 53-year-old man with chronic pulmonary aspergillosis underwent pneumonectomy of the left lung 15 days prior to the onset of DAH, which was confirmed by bronchoalveloar lavage. The battery of diagnostic evaluations performed revealed no other positive etiological factor, leading to the diagnosis of DAH possibly induced by intravenous ITCZ with a positive drug lymphocyte stimulation test. The patient did not respond to pulse methylprednisolone therapy, but responded dramatically to direct hemoperfusion using a polymyxin B-immobilized fiber column (PMX) therapy.

Details

Language :
English
ISSN :
1349-7235
Volume :
49
Issue :
5
Database :
MEDLINE
Journal :
Internal medicine (Tokyo, Japan)
Publication Type :
Academic Journal
Accession number :
20190492
Full Text :
https://doi.org/10.2169/internalmedicine.49.2735