Back to Search Start Over

Genome-wide association study reveals multiple loci associated with primary tooth development during infancy.

Authors :
Pillas D
Hoggart CJ
Evans DM
O'Reilly PF
Sipilä K
Lähdesmäki R
Millwood IY
Kaakinen M
Netuveli G
Blane D
Charoen P
Sovio U
Pouta A
Freimer N
Hartikainen AL
Laitinen J
Vaara S
Glaser B
Crawford P
Timpson NJ
Ring SM
Deng G
Zhang W
McCarthy MI
Deloukas P
Peltonen L
Elliott P
Coin LJ
Smith GD
Jarvelin MR
Source :
PLoS genetics [PLoS Genet] 2010 Feb 26; Vol. 6 (2), pp. e1000856. Date of Electronic Publication: 2010 Feb 26.
Publication Year :
2010

Abstract

Tooth development is a highly heritable process which relates to other growth and developmental processes, and which interacts with the development of the entire craniofacial complex. Abnormalities of tooth development are common, with tooth agenesis being the most common developmental anomaly in humans. We performed a genome-wide association study of time to first tooth eruption and number of teeth at one year in 4,564 individuals from the 1966 Northern Finland Birth Cohort (NFBC1966) and 1,518 individuals from the Avon Longitudinal Study of Parents and Children (ALSPAC). We identified 5 loci at P<5x10(-8), and 5 with suggestive association (P<5x10(-6)). The loci included several genes with links to tooth and other organ development (KCNJ2, EDA, HOXB2, RAD51L1, IGF2BP1, HMGA2, MSRB3). Genes at four of the identified loci are implicated in the development of cancer. A variant within the HOXB gene cluster associated with occlusion defects requiring orthodontic treatment by age 31 years.<br />Competing Interests: The authors have declared that no competing interests exist.

Details

Language :
English
ISSN :
1553-7404
Volume :
6
Issue :
2
Database :
MEDLINE
Journal :
PLoS genetics
Publication Type :
Academic Journal
Accession number :
20195514
Full Text :
https://doi.org/10.1371/journal.pgen.1000856