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Distinct contribution of working memory and social comprehension failures in neuropsychological impairment in schizophrenia.
- Source :
-
The Journal of nervous and mental disease [J Nerv Ment Dis] 2010 Mar; Vol. 198 (3), pp. 206-12. - Publication Year :
- 2010
-
Abstract
- Neuropsychological impairment represents a core characteristic of schizophrenia, but its underlying components have yet to be clearly established. Using a comprehensive battery of standardized measures of intelligence, declarative episodic memory, and executive function, we hypothesized that the variance in neuropsychological performance in schizophrenia may reflect at least 2 distinct sources related to failures of (a) the central executive division of working memory and (b) social comprehension. In comparison to age-matched controls, patients with schizophrenia showed not only overall reduced scores on Wechsler intelligence and memory scales and Wisconsin Card Sorting Test (WCST) of executive function, but they also demonstrated different patterns of performance for each of these tests. Hierarchical regression revealed executive attentional control, measured by Trails B performance speed, and social comprehension, measured by Wechsler IQ Comprehension and Picture Arrangement subtests, each accounted for a unique and specific proportion of variance in test scores for the patient group, even when controlling for general intelligence. Failures in social comprehension and executive attentional control may account for distinct sources of variance in the neuropsychological impairment of schizophrenia.
- Subjects :
- Adolescent
Adult
Cognition Disorders psychology
Comprehension physiology
Diffusion Tensor Imaging statistics & numerical data
Executive Function physiology
Female
Humans
Male
Memory, Short-Term physiology
Middle Aged
Perceptual Disorders diagnosis
Perceptual Disorders psychology
Psychiatric Status Rating Scales
Psychometrics
Schizophrenia physiopathology
Wechsler Scales statistics & numerical data
Cognition Disorders diagnosis
Neuropsychological Tests statistics & numerical data
Schizophrenia diagnosis
Schizophrenic Psychology
Social Perception
Subjects
Details
- Language :
- English
- ISSN :
- 1539-736X
- Volume :
- 198
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of nervous and mental disease
- Publication Type :
- Academic Journal
- Accession number :
- 20215998
- Full Text :
- https://doi.org/10.1097/NMD.0b013e3181d14143