Disseminated Scedosporium/Pseudallescheria infection after double-lung transplantation in patients with cystic fibrosis.

Authors :: Morio F
Horeau-Langlard D
Gay-Andrieu F
Talarmin JP
Haloun A
Treilhaud M
Despins P
Jossic F
Nourry L
Danner-Boucher I
Pattier S
Bouchara JP
Le Pape P
Miegeville M
Source :: Journal of clinical microbiology [J Clin Microbiol] 2010 May; Vol. 48 (5), pp. 1978-82. Date of Electronic Publication: 2010 Mar 10.
Publication Year :: 2010
Abstract: We report a case of disseminated Scedosporium/Pseudallescheria infection due to Pseudallescheria boydii sensu stricto after lung transplantation in a patient with cystic fibrosis. Dissemination occurred under voriconazole. Despite surgery and combination therapy with voriconazole, caspofungin, and terbinafine, the patient died 8 months after transplantation. Previously reported cases are reviewed.

Subjects :: Adult
Antifungal Agents therapeutic use
Brain diagnostic imaging
Caspofungin
Chemoprevention methods
DNA, Fungal chemistry
DNA, Fungal genetics
Echinocandins therapeutic use
Fatal Outcome
Female
Humans
Lipopeptides
Lung Diseases, Fungal drug therapy
Lung Diseases, Fungal microbiology
Lung Diseases, Fungal surgery
Magnetic Resonance Imaging
Microbial Sensitivity Tests
Microscopy
Molecular Sequence Data
Naphthalenes therapeutic use
Pseudallescheria classification
Pseudallescheria cytology
Pseudallescheria genetics
Pyrimidines therapeutic use
RNA, Fungal genetics
RNA, Ribosomal, 28S genetics
Radiography
Scedosporium classification
Scedosporium cytology
Scedosporium genetics
Sequence Analysis, DNA
Terbinafine
Triazoles therapeutic use
Voriconazole
Cystic Fibrosis therapy
Lung Diseases, Fungal diagnosis
Lung Transplantation adverse effects
Pseudallescheria isolation & purification
Scedosporium isolation & purification

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