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Comparison between fixed-dose, intracoronary bolus-only versus standard weight-adjusted dose, intravenous bolus and infusion administration of abciximab in patients undergoing primary percutaneous coronary intervention.
- Source :
-
International journal of cardiology [Int J Cardiol] 2010 Nov 19; Vol. 145 (2), pp. 355-357. Date of Electronic Publication: 2010 Mar 15. - Publication Year :
- 2010
-
Abstract
- We studied the safety and effectiveness of fixed-dose, intracoronary bolus-only abciximab in 195 patients who underwent primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. The patients were divided into 2 groups: Group A (n=120, 61.5%) received fixed-dose, intracoronary bolus-only, abciximab 10 mg; and Group B (n=75, 38.5%) received standard intravenous bolus (0.25 mg/kg) and maintenance abciximab infusion of 0.125 μg/kg/min for 12 h. There was no statistically significant difference in the baseline and post-procedure TIMI flow between Groups A and B. Final TIMI 3 flow was achieved in 90.0% and 89.3% of the patients in Groups A and B, respectively (p=0.14). Final TIMI myocardial perfusion grade 2/3 was achieved in 92.5% and 96.0% of the patients in Groups A and B, respectively (p=0.45). The six-month clinical outcomes were similar between Groups A and B (8.3% versus 5.3%, p=0.62).<br /> (Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Abciximab
Adult
Aged
Female
Follow-Up Studies
Humans
Infusions, Intra-Arterial
Infusions, Intravenous
Injections, Intra-Arterial
Injections, Intravenous
Male
Middle Aged
Myocardial Infarction physiopathology
Myocardial Infarction therapy
Angioplasty, Balloon, Coronary methods
Antibodies, Monoclonal administration & dosage
Immunoglobulin Fab Fragments administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1874-1754
- Volume :
- 145
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- International journal of cardiology
- Publication Type :
- Report
- Accession number :
- 20227778
- Full Text :
- https://doi.org/10.1016/j.ijcard.2010.02.017