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Endogenous hormones, androgen receptor CAG repeat length and fluid cognition in middle-aged and older men: results from the European Male Ageing Study.
- Source :
-
European journal of endocrinology [Eur J Endocrinol] 2010 Jun; Vol. 162 (6), pp. 1155-64. Date of Electronic Publication: 2010 Mar 15. - Publication Year :
- 2010
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Abstract
- Objective: Data remain divergent regarding the activational effects of endogenous hormones on adult cognitive function. We examined the association between cognition, hormones and androgen receptor (AR) CAG repeat length in a large cohort of men.<br />Design: Community-based, cross-sectional study of 3369 men aged 40-79 years.<br />Methods: Cognition tests were the Rey-Osterrieth Complex Figure, Camden Topographical Recognition Memory and Digit-Symbol Substitution. A fluid cognition (FC) z-score was computed from the individual tests. Testosterone, oestradiol (OE(2)) and 5alpha-dihydrotestosterone were measured by gas chromatography-mass spectrometry; DHEAS, LH, FSH and sex hormone-binding globulin (SHBG) by electrochemiluminescence. Free testosterone and OE(2) were calculated from total hormone, SHBG and albumin. CAG repeat lengths were assayed by PCR genotyping.<br />Results: Total testosterone and free testosterone were associated with higher FC z-scores, LH and FSH with lower FC z-scores in age-adjusted linear regressions. After adjusting for health, lifestyle and centre, a modest association was only observed between DHEAS and a lower FC z-score (beta=-0.011, P=0.02), although this was driven by subjects with DHEAS levels >10 micromol/l. Locally weighted plots revealed no threshold effects between hormones and FC. There was no association between CAG repeat length and FC z-score after adjustment for age and centre (beta=-0.007, P=0.06), nor any interaction effect between CAG repeat length and hormones.<br />Conclusion: Our results suggest that endogenous hormones are not associated with a vision-based measure of FC among healthy, community-dwelling men. Further studies are warranted to determine whether 'high' DHEAS levels are associated with poorer performance on a broader range of neuropsychological tests.
- Subjects :
- Adult
Age Factors
Aged
Europe
Humans
Male
Middle Aged
Neuropsychological Tests
Reference Values
Regression Analysis
Surveys and Questionnaires
Aging physiology
Cognition physiology
Dihydrotestosterone blood
Estradiol blood
Receptors, Androgen genetics
Testosterone blood
Trinucleotide Repeats genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1479-683X
- Volume :
- 162
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- European journal of endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 20231367
- Full Text :
- https://doi.org/10.1530/EJE-09-0970