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Human herpesvirus-8 in northwestern China: epidemiology and characterization among blood donors.
- Source :
-
Virology journal [Virol J] 2010 Mar 17; Vol. 7, pp. 62. Date of Electronic Publication: 2010 Mar 17. - Publication Year :
- 2010
-
Abstract
- Background: Human herpes virus 8 (HHV-8) is the etiologic agent associated with development of classical, AIDS-related, iatrogenic, and endemic Kaposi's sarcoma (KS). Several studies provide strong evidence that HHV-8 can be transmitted by blood transfusion. We evaluated the seroprevalence and potential risk factors of HHV-8 infection in blood donors in one region. We surveyed HHV-8 infection among 4461 blood donors in Xinjiang, China, a unique endemic area for HHV-8 and KS.<br />Results: The HHV-8 seroprevalence was higher in local minority groups which comprise most KS cases in China, than in Han people. HHV-8 prevalence was 18.6% in the Han ethnic group, 25.9% in Uygur subjects, 29.2% in Kazak subjects, 36.8% in Mongolian subjects, and 21.9% in other ethnic groups. In several subgroups, the time of donation of whole blood seemed to be a risk factor. In HHV-8-seropositive subjects, a larger fraction of local minorities (23.9%) had high HHV-8 titers than that of Han subjects (9.2%). HHV-8 infection was associated with ethnicity and residence.<br />Conclusion: HHV-8 seroprevalence was significantly high among blood donors in Xinjiang, where the prevalence of KS correlates with HHV-8 prevalence and titers in Uygur and Kazak ethnic groups. Blood exposure represented by the frequency of blood donation indicated a possible blood-borne transmission route of HHV-8 in Xinjiang. Detecting anti-HHV-8 antibodies before donation in this region is therefore important.
- Subjects :
- Adult
China epidemiology
Female
Herpesviridae Infections transmission
Humans
Male
Middle Aged
Seroepidemiologic Studies
Young Adult
Antibodies, Viral blood
Blood Donors
Blood-Borne Pathogens isolation & purification
Herpesviridae Infections epidemiology
Herpesviridae Infections virology
Herpesvirus 8, Human isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1743-422X
- Volume :
- 7
- Database :
- MEDLINE
- Journal :
- Virology journal
- Publication Type :
- Academic Journal
- Accession number :
- 20236530
- Full Text :
- https://doi.org/10.1186/1743-422X-7-62