Back to Search
Start Over
Comparison of long-term results of drug-eluting stent and bare metal stent implantation in heart transplant recipients with coronary artery disease.
- Source :
-
Kardiologia polska [Kardiol Pol] 2010 Feb; Vol. 68 (2), pp. 131-4. - Publication Year :
- 2010
-
Abstract
- Background: Transplanted heart coronary artery disease (TxCAD) may occur in a significant proportion of patients following cardiac transplantation. Drug-eluting stents (DES) have been successfully used in patients with CAD, but their efficacy in TxCAD patients has not been well established.<br />Aim: To compare long-term results of intracoronary implantation of DES and BMS in patients suffering from TxCAD.<br />Methods: We performed a retrospective analysis of all intracoronary stent implantations for TxCAD with at least one control coronary angiography performed during follow-up. We identified 28 DES (all sirolimus-eluting stents, SES) and 28 BMS implantations in 23 patients. The mean follow-up time was 410+/-58 days after DES, and 572+/-434 days after BMS implantation (p=0.004). We compared the occurrence of in-stent restenosis (ISR) in DES and BMS, and survival of patients in the context of risk factors that were identified for each stent implantation separately.<br />Results: There were 2 (7%) ISR revealed in DES patients (mean time from PCI to restenosis 492+/-58 days) vs. 17 (61%) ISR in BMS patients (mean time from PCI to restenosis 475+/-345 days) (p<0.001). There were 3 (18%) deaths in patients with DES, 4 (31%) in patients with BMS, and 1 (14%) in a patient with DES and BMS (NS). The risk factor profile was comparable, except for higher age at the time of transplantation (46+/-7 vs. 41+/-6 years, p=0.011) and stent implantation (54+/-7 vs. 49+/-6 years, p<0.001) for DES.<br />Conclusion: Favourable long-term results of DES compared with BMS implantation for TxCAD suggest the preferential use of DES in heart transplant recipients.
- Subjects :
- Adult
Coronary Angiography
Coronary Disease etiology
Female
Follow-Up Studies
Heart Failure surgery
Humans
Male
Middle Aged
Recurrence
Retrospective Studies
Risk Factors
Sirolimus administration & dosage
Stents
Survival Rate
Coronary Disease therapy
Drug-Eluting Stents
Heart Transplantation adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 0022-9032
- Volume :
- 68
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Kardiologia polska
- Publication Type :
- Academic Journal
- Accession number :
- 20301021