Back to Search
Start Over
Influence of magnolol on the secretion of alpha-toxin by Staphylococcus aureus.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2010 Mar 12; Vol. 15 (3), pp. 1679-89. Date of Electronic Publication: 2010 Mar 12. - Publication Year :
- 2010
-
Abstract
- In this study we investigated the antimicrobial activity of magnolol on Staphylococcus aureus. The minimal inhibitory concentrations of magnolol against 31 S. aureus strains ranged from 4-32 microg/mL. In addition, hemolysin assays, Western blotting, and real-time RT-PCR were performed to investigate the effect of magnolol on alpha-toxin secretion by both methicillin-sensitive S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA). The results indicated that sub-inhibitory concentrations of magnolol dose-dependently inhibited the transcription of hla (the gene encoding alpha-toxin) in S. aureus, resulting in a reduction of alpha-toxin secretion and, thus, hemolytic activities.
- Subjects :
- Animals
Bacterial Toxins
Blotting, Western
Hemolysis drug effects
Rabbits
Reverse Transcriptase Polymerase Chain Reaction
Staphylococcus aureus growth & development
Staphylococcus aureus metabolism
Biphenyl Compounds pharmacology
Hemolysin Proteins metabolism
Lignans pharmacology
Staphylococcus aureus drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 15
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 20336007
- Full Text :
- https://doi.org/10.3390/molecules15031679