The functions of the HIV1 protein Vpr and its action through the DCAF1.DDB1.Cullin4 ubiquitin ligase.

Authors :: Casey L
Wen X
de Noronha CM
Source :: Cytokine [Cytokine] 2010 Jul; Vol. 51 (1), pp. 1-9. Date of Electronic Publication: 2010 Mar 27.
Publication Year :: 2010
Abstract: Among the proteins encoded by human and simian immunodeficiency viruses (HIV and SIV) at least three, Vif, Vpu and Vpr, subvert cellular ubiquitin ligases to block the action of anti-viral defenses. This review focuses on Vpr and its HIV2/SIV counterparts, Vpx and Vpr, which all engage the DDB1.Cullin4 ubiquitin ligase complex through the DCAF1 adaptor protein. Here, we discuss the multiple functions that have been linked to Vpr expression and summarize the current knowledge on the role of the ubiquitin ligase complex in carrying out a subset of these activities.<br /> (Copyright 2010 Elsevier Ltd. All rights reserved.)

Subjects :: Amino Acid Sequence
Gene Products, vpr chemistry
HIV-1 pathogenicity
HIV-1 physiology
Humans
Molecular Sequence Data
Protein Serine-Threonine Kinases
Ubiquitin-Protein Ligases
Virus Replication
Carrier Proteins metabolism
Cullin Proteins metabolism
DNA-Binding Proteins metabolism
Gene Products, vpr metabolism
HIV-1 metabolism

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