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Antiretroviral drug resistance in HIV-1-infected patients with low-level viremia.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2010 May 01; Vol. 201 (9), pp. 1303-7. - Publication Year :
- 2010
-
Abstract
- This study characterized the prevalence and patterns of antiretroviral-drug-resistance mutations according to plasma human immunodeficiency virus type 1 (HIV-1) RNA load in a large population of patients with HIV-1 infection who underwent testing for resistance mutations in routine clinical practice. HIV-1 genotypic resistance test results with linked clinical data were obtained from national resistance and clinical databases in the United Kingdom. Among 7861 tests, detection of > or =1 resistance mutation was most frequent at viral loads of 300-10,000 copies/mL and decreased statistically significantly at viral loads of >10,000 copies/mL. Major resistance mutations were commonly detected in the subset of tests that were performed among patients with viral loads of <1000 copies/mL (1001 [12.7%] of 7861 tests). We conclude that HIV-1 genotypic resistance testing is informative for patients with low viral loads.
- Subjects :
- Adult
Anti-HIV Agents pharmacology
Cohort Studies
Drug Resistance, Viral
Female
Genotype
HIV-1 genetics
Humans
Male
Middle Aged
Prevalence
Risk
United Kingdom epidemiology
Viral Load drug effects
Viremia virology
Anti-HIV Agents therapeutic use
HIV Infections drug therapy
HIV-1 drug effects
Viremia drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6613
- Volume :
- 201
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 20350161
- Full Text :
- https://doi.org/10.1086/651618