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Long-term changes in serum cholesterol level does not influence the progression of coronary calcification.
Long-term changes in serum cholesterol level does not influence the progression of coronary calcification.
- Source :
-
International journal of cardiology [Int J Cardiol] 2011 Jul 15; Vol. 150 (2), pp. 130-4. Date of Electronic Publication: 2010 Mar 29. - Publication Year :
- 2011
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Abstract
- Background: A number of reports controversially describe the influence of cholesterol level and lipid-lowering treatment (LLT) on the progression of coronary calcium (CC). We tested the hypothesis that long-term changes in serum cholesterol (CL) would affect the progression of CC.<br />Methods: The study population comprised 510 patients with stable angina pectoris, mean age of 63 ± 9 years. At baseline 372 patients received statin and/or fibrate (LLT group) while 138 patients did not (No-LLT at baseline group). Spiral CT every 24 months was used to track the progression of CC over a median 5.6 year follow-up.<br />Results: CL decreased during follow-up in both groups, but more pronouncedly in patients with LLT. The changes in total calcium score (TCS) were similar in both groups (p=0.3). Changes in CL during follow-up were not associated with CC: TCS increased by 501 ± 63 from baseline in the 1st (upper) quartile, and by 350 ± 44, 403 ± 41 and 480 ± 56 in the 2nd, 3rd, and 4th quartiles of CL longitudinal changes (p = 0.2), respectively. Baseline TCS and its changes were not correlated with baseline CL and its changes. New calcified lesions were diagnosed in 132 (28.2%) out of the 467 patients available for this analysis, without significant difference between groups (p=0.4). Multivariate analysis demonstrated that only baseline TCS (p < 0.001), body mass index (p = 0.007) and age (p = 0.006) were independent predictors for the TCS changes.<br />Conclusions: Longitudinal CL changes do not seem to have a measurable effect on the rate of progression of CC.<br /> (Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1874-1754
- Volume :
- 150
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- International journal of cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 20350769
- Full Text :
- https://doi.org/10.1016/j.ijcard.2010.03.001