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Is cytology reliable for epidermal growth factor receptor gene evaluation in non-small cell lung cancer?
- Source :
-
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer [J Thorac Oncol] 2010 Apr; Vol. 5 (4), pp. 551-3. - Publication Year :
- 2010
-
Abstract
- Background: Epidermal growth factor receptor (EGFR) gene copy number has been proposed as predictor of response to epidermal growth factor receptor tyrosine kinase inhibitors in advanced non-small cell lung cancer (NSCLC).<br />Methods: Cytologic and matched histologic samples from 33 primary non-small cell lung cancers were analyzed by fluorescence in situ hybridization (FISH) for epidermal growth factor receptor gene.<br />Results: FISH was positive in 52% and negative in 35% of the 31 matched evaluable samples. Four of 31 (13%) cases were discordant (K = 0.736; p < 0.001).<br />Conclusion: Our data support the feasibility and reliability of epidermal growth factor receptor gene assessment by FISH on cytology.
- Subjects :
- Adenocarcinoma genetics
Carcinoma, Non-Small-Cell Lung genetics
Carcinoma, Squamous Cell genetics
Feasibility Studies
Humans
Lung Neoplasms genetics
Neoplasm Staging
Prognosis
Survival Rate
Adenocarcinoma pathology
Carcinoma, Non-Small-Cell Lung pathology
Carcinoma, Squamous Cell pathology
ErbB Receptors genetics
Gene Dosage
In Situ Hybridization, Fluorescence
Lung Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1556-1380
- Volume :
- 5
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 20357620
- Full Text :
- https://doi.org/10.1097/JTO.0b013e3181ce3b28