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CD209 (DC-SIGN) -336A>G promoter polymorphism and severe acute respiratory syndrome in Hong Kong Chinese.
- Source :
-
Human immunology [Hum Immunol] 2010 Jul; Vol. 71 (7), pp. 702-7. Date of Electronic Publication: 2010 May 04. - Publication Year :
- 2010
-
Abstract
- CD209 (DC-SIGN) is an important C-type lectin which acts a receptor of many pathogens. The single nucleotide polymorphism (SNP) -336A>G in the CD209 promoter has been demonstrated to regulate promoter activity and to be associated with several important infectious diseases, such as human immunodeficiency virus-1 (HIV-1), Mycobacterium tuberculosis, and Dengue fever. CD209 facilitates severe acute respiratory syndrome (SARS)-coronavirus spike protein-bearing pseudotype driven infection of permissive cells in vitro. In keeping with previously published findings, our in vitro studies confirmed that this SNP modulates gene promoter activity. Genetic association analysis of this SNP with clinico-pathologic outcomes in 824 serologic confirmed SARS patients showed that the -336AG/GG genotype SARS patients was associated with lower standardized lactate-dehydrogenase (LDH) levels compared with the -336AA patients (p = 0.014, odds ratio = 0.40). High LDH levels are known to be an independent predictor for poor clinical outcome, probably related to tissue destruction from immune hyperactivity. Hence, SARS patients with the CD209 -336 AA genotype carry a 60% chance of having a poorer prognosis. This association is in keeping with the role of CD209 in modulating immune response to viral infection. The relevance of these findings for other infectious diseases and inflammatory conditions would be worth investigating.<br /> (Copyright 2010 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Antigens, CD genetics
Asian People genetics
Cell Adhesion Molecules metabolism
DNA metabolism
DNA Probes genetics
Electrophoretic Mobility Shift Assay
Female
Gene Frequency genetics
Genotype
HeLa Cells
Heterozygote
Homozygote
Hong Kong
Humans
L-Lactate Dehydrogenase blood
Lectins, C-Type metabolism
Male
Middle Aged
Nuclear Proteins metabolism
Protein Binding genetics
Receptors, Cell Surface metabolism
Severe Acute Respiratory Syndrome blood
Sp1 Transcription Factor genetics
Transcription Factor AP-2 genetics
Transfection
Cell Adhesion Molecules genetics
Lectins, C-Type genetics
Polymorphism, Single Nucleotide genetics
Promoter Regions, Genetic genetics
Receptors, Cell Surface genetics
Severe Acute Respiratory Syndrome genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1166
- Volume :
- 71
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Human immunology
- Publication Type :
- Academic Journal
- Accession number :
- 20359516
- Full Text :
- https://doi.org/10.1016/j.humimm.2010.03.006