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Archaeal lipid mucosal vaccine adjuvant and delivery system.
- Source :
-
Expert review of vaccines [Expert Rev Vaccines] 2010 Apr; Vol. 9 (4), pp. 431-40. - Publication Year :
- 2010
-
Abstract
- Archaeal polar lipids are being evaluated as adjuvants/vaccine delivery systems for mucosal vaccines that can provide protection against pathogens that enter the human host via the mucosal surfaces. Archaeosomes, liposomes made from polar lipids extracted from Archaea, with encapsulated antigens elicit strong antigen-specific systemic immune responses upon systemic or intranasal immunization, but fail to generate mucosal immune responses. However, intranasal immunization of mice with the archaeal lipid mucosal vaccine adjuvant and delivery (AMVAD) system, obtained by the interaction of archaeosomes/antigens with multivalent cations, induces robust, antigen-specific IgA responses in nasal and vaginal mucosa, feces, bile, and serum. In addition, strong antigen-specific systemic antibody (serum IgG, IgG(1) and IgG(2a)) and cell-mediated responses, including CD8(+) cytotoxic T lymphocyte, are generated. The responses are sustained over time and are subject to good memory-boost responses. The AMVAD formulations are stable during storage, have a good safety profile and show protective efficacy in a murine model of infection/challenge.
- Subjects :
- Animals
Archaea ultrastructure
Drug Delivery Systems trends
Humans
Immunity, Mucosal immunology
Intestinal Mucosa immunology
Intestinal Mucosa ultrastructure
Lipids administration & dosage
Mouth Mucosa immunology
Mouth Mucosa ultrastructure
Nasal Mucosa immunology
Nasal Mucosa ultrastructure
Adjuvants, Immunologic administration & dosage
Archaea immunology
Drug Delivery Systems methods
Lipids immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1744-8395
- Volume :
- 9
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Expert review of vaccines
- Publication Type :
- Academic Journal
- Accession number :
- 20370552
- Full Text :
- https://doi.org/10.1586/erv.10.34