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Disease activity and damage accrual during the early disease course in a multinational inception cohort of patients with systemic lupus erythematosus.
- Source :
-
Lupus [Lupus] 2010 Jul; Vol. 19 (8), pp. 949-56. Date of Electronic Publication: 2010 Apr 07. - Publication Year :
- 2010
-
Abstract
- An inception cohort of patients with systemic lupus erythematosus from 14 European centres was followed for up to 5 years in order to describe the current early disease course. At inclusion patients (n = 200, 89% female, mean age 35 years, 97% Caucasian, mean SLEDAI 12.2) fulfilled a mean of 6.5 ACR classification criteria. The most prevalent criteria were antinuclear Ab presence (97%) followed by anti-dsDNA Ab (74%), arthritis (69%), leukocytopenia (54%) and malar rash (53%), antiphospholipid Ab (48%) and anti-synovial membrane Ab (21.6%). Clinical signs of lupus nephritis (LN) were present in 39% with biopsy-confirmed LN seen in 25%. Frequent additional findings were hypocomplementaemia (54%), anti-SSA Ab (49%), alopecia (26%) and Raynaud's phenomenon (31%). There were few regional differences in disease presentation and management. One and 5-year survival rates were 99% and 97% respectively. During the mean follow-up of 4.1 years 25% entered a state of early disease quiescence by global physician assessment, but the overall risk of subsequent flare was 60%. Maximum SLEDAI scores decreased over time, but 45% of patients accrued damage (SDI >or=1) for which baseline presence of proteinuria and persistent disease activity were independent predictors. The results indicate minor differences in SLE presentation and treatment within various regions of Europe and a high diagnostic reliance on anti-dsDNA Ab. Despite early reductions in disease activity and improved mortality, the risk for disease flare and damage development is, however, still substantial, especially in patients not entering an early remission.
- Subjects :
- Adult
Antibodies, Antinuclear blood
Cohort Studies
Europe
Female
Humans
Immunosuppressive Agents therapeutic use
Lupus Erythematosus, Systemic diagnosis
Lupus Erythematosus, Systemic therapy
Male
Middle Aged
Mortality
Young Adult
Disease Progression
Lupus Erythematosus, Systemic pathology
Lupus Erythematosus, Systemic physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1477-0962
- Volume :
- 19
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Lupus
- Publication Type :
- Academic Journal
- Accession number :
- 20375124
- Full Text :
- https://doi.org/10.1177/0961203310366572