Cucurbitane-type triterpenoids from Momordica charantia.

Authors :: Ma J
Whittaker P
Keller AC
Mazzola EP
Pawar RS
White KD
Callahan JH
Kennelly EJ
Krynitsky AJ
Rader JI
Source :: Planta medica [Planta Med] 2010 Oct; Vol. 76 (15), pp. 1758-61. Date of Electronic Publication: 2010 Apr 08.
Publication Year :: 2010
Abstract: One new cucurbitane-type triterpenoid glycoside, momordicoside U (1), together with five known cucurbitane-type triterpenoids and related glycosides, 3β,7 β,25-trihydroxycucurbita-5,23 (E)-dien-19-al (2), momordicine I (3), momordicine II (4), 3-hydroxycucurbita-5,24-dien-19-al-7,23-di-O-β-glucopyranoside (5), and kuguaglycoside G (6), were isolated from the whole plant of Momordica charantia. Their structures were determined by chemical and spectroscopic methods. Momordicoside U (1) was evaluated for insulin secretion activity in an in vitro insulin secretion assay and displayed moderate activity.<br /> (© Georg Thieme Verlag KG Stuttgart · New York.)