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Interactions between innate and adaptive immunity in asthma pathogenesis: new perspectives from studies on acute exacerbations.
- Source :
-
The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2010 May; Vol. 125 (5), pp. 963-72; quiz 973-4. Date of Electronic Publication: 2010 Apr 15. - Publication Year :
- 2010
-
Abstract
- Asthma is a complex multigenic disease. The most frequently encountered form is atopic asthma, which is at its highest prevalence during childhood/young adulthood, and this represents the main focus of this review. The primary risk factor for atopic asthma is sensitization to perennial aeroallergens resulting from a failure to generate protective immunologic tolerance. This tolerance process is orchestrated by airway mucosal dendritic cells and normally results in programming of regulatory T cells, which inhibit activation of the T(H)2 memory cells that, among other activities, drive IgE production and prime the effector populations responsible for IgE-mediated tissue damage. Emerging evidence highlights the complexity of this process, in particular the iterative nature of the underlying interactions between innate and adaptive immune mechanisms in which virtually every signal emanating from one cellular compartment provokes an answering response from the other. To further complicate this picture, the local mesenchyme can also interpose signals to fine tune immune responses to optimally meet local microenvironmental needs. Perturbation of the balance between these interlinked innate and adaptive immune pathways is increasingly believed to be the basis for disease expression, and in the specific case of atopic asthma, the prototypic example of this (discussed below) is acute exacerbations triggered by viral infections.<br /> (Copyright 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.)
- Subjects :
- Allergens adverse effects
Allergens immunology
Animals
Child
Child, Preschool
Dendritic Cells immunology
Humans
Hypersensitivity, Immediate physiopathology
Mice
T-Lymphocytes, Regulatory immunology
Virus Diseases virology
Adaptive Immunity
Asthma immunology
Asthma physiopathology
Hypersensitivity, Immediate immunology
Immunity, Innate
Virus Diseases immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6825
- Volume :
- 125
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Journal of allergy and clinical immunology
- Publication Type :
- Academic Journal
- Accession number :
- 20394979
- Full Text :
- https://doi.org/10.1016/j.jaci.2010.02.011