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Chronic intestinal helminth infections are associated with immune hyporesponsiveness and induction of a regulatory network.
- Source :
-
Infection and immunity [Infect Immun] 2010 Jul; Vol. 78 (7), pp. 3160-7. Date of Electronic Publication: 2010 Apr 19. - Publication Year :
- 2010
-
Abstract
- Helminth infections have been associated with protection against allergy and autoimmune diseases. We investigated the effects of chronic infections with Ascaris lumbricoides and Trichuris trichiura (measured twice over a 5-year period) on cytokine and antibody responses. We collected blood from 1,060 children aged 4 to 11 years living in a poor urban area of Brazil and measured Th1 (gamma interferon [IFN-gamma]) and Th2 (interleukin-5 [IL-5] and IL-13) cytokines and the regulatory cytokine IL-10 in unstimulated and stimulated (with mitogen or A. lumbricoides antigens) cultures of peripheral blood leukocytes and levels of total IgE and anti-A. lumbricoides IgG4 and IgE in serum. Intestinal helminth infections were associated with an increased proportion of children producing IL-5 in response to A. lumbricoides and producing IL-10 spontaneously, especially among coinfected and chronically infected children. Helminth infections were associated with a generalized suppression of cytokine responses to mitogen. Levels of total IgE and anti-A. lumbricoides IgG4 and IgE were especially elevated in chronically infected children. In conclusion, intestinal helminth infections were associated with a typical Th2 immune response profile and with the induction of immune hyporesponsiveness that was associated with greater frequencies of the production of spontaneous IL-10.
- Subjects :
- Animals
Antibodies, Helminth blood
Antibodies, Helminth immunology
Child
Child, Preschool
Female
Humans
Immunity, Humoral immunology
Immunoglobulin E blood
Immunoglobulin E immunology
Immunoglobulin G blood
Immunoglobulin G immunology
Interferon-gamma blood
Interferon-gamma immunology
Interleukin-10 blood
Interleukin-10 immunology
Interleukin-13 blood
Interleukin-13 immunology
Interleukin-5 blood
Interleukin-5 immunology
Male
Ascariasis immunology
Ascaris lumbricoides immunology
Trichuriasis immunology
Trichuris immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1098-5522
- Volume :
- 78
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Infection and immunity
- Publication Type :
- Academic Journal
- Accession number :
- 20404082
- Full Text :
- https://doi.org/10.1128/IAI.01228-09