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[Adult T-cell leukemia induced by HTLV-1: before and after HBZ].
- Source :
-
Medecine sciences : M/S [Med Sci (Paris)] 2010 Apr; Vol. 26 (4), pp. 391-6. - Publication Year :
- 2010
-
Abstract
- Adult T-cell leukemia (ATL) is an often fatal leukemia of CD4+ T lymphocytes associated with a complex retrovirus, human T-cell leukemia virus type 1 (HTLV-1). Although the viral Tax protein is involved in the proliferation of infected cells during the preleukemic stages, Tax expression is not systematically detected in primary leukemic cells. In 2002, we described the characterization of a novel viral protein that we have termed HBZ for HTLV-1 bZIP factor. This viral factor is encoded on the antisense strand of HTLV-1 proviral DNA, demonstrating the existence of antisense transcription from a promoter located in the 3' LTR. HBZ can negatively control the expression of the other viral proteins by blocking the interaction between Tax and ATF/CREB factors and the recruitment of CBP/p300 by Tax on the promoter. Moreover, recent studies found that the viral HBZ gene was always expressed in leukemic cells, suggesting its involvement in the progression of the infected cells towards malignancy.
- Subjects :
- Activating Transcription Factors metabolism
Animals
Basic-Leucine Zipper Transcription Factors genetics
Cell Division
Cyclic AMP Response Element-Binding Protein metabolism
Gene Products, tax metabolism
Genes, pX
Human T-lymphotropic virus 1 genetics
Human T-lymphotropic virus 1 pathogenicity
Humans
Leucine Zippers genetics
Leucine Zippers physiology
Leukemia-Lymphoma, Adult T-Cell genetics
Leukemia-Lymphoma, Adult T-Cell immunology
Models, Genetic
Promoter Regions, Genetic genetics
Proviruses genetics
RNA, Small Interfering pharmacology
Rabbits
Retroviridae Proteins
Terminal Repeat Sequences genetics
Transcription, Genetic drug effects
Transcription, Genetic genetics
Viral Proteins genetics
p300-CBP Transcription Factors metabolism
Basic-Leucine Zipper Transcription Factors physiology
Cell Transformation, Viral genetics
Gene Expression Regulation, Viral
Human T-lymphotropic virus 1 physiology
Leukemia-Lymphoma, Adult T-Cell virology
Viral Proteins physiology
Subjects
Details
- Language :
- French
- ISSN :
- 0767-0974
- Volume :
- 26
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Medecine sciences : M/S
- Publication Type :
- Academic Journal
- Accession number :
- 20412744
- Full Text :
- https://doi.org/10.1051/medsci/2010264391