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Drug-eluting stents for the treatment of vertebral artery origin stenosis.
- Source :
-
Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists [J Endovasc Ther] 2010 Apr; Vol. 17 (2), pp. 232-40. - Publication Year :
- 2010
-
Abstract
- Purpose: To present our experience with the use of drug-eluting stents (DES) in patients with symptomatic vertebral artery ostium stenosis (VAOS).<br />Methods: Between 2003 and 2008, 28 consecutive patients (17 men; mean age 66 years) with symptomatic extracranial vertebral artery stenosis were treated with a paclitaxel-eluting stent. All patients were prospectively scheduled for serial clinical, duplex, and angiographic follow-up to identify restenosis.<br />Results: After stent implantation, the mean stenosis was reduced from 68% to 9%. There were no periprocedural neurological complications. After a mean follow-up of 16 months (range 5-41), no strokes, worsening of symptoms, or deaths occurred. Angiographic restenosis >50% was seen in 6 (21.4%) patients. Restenosis occurred significantly more often in patients with an ipsilateral subclavian artery stenosis (p = 0.01). Radiography during follow-up angiography revealed stent fracture in 1 patient and stent compression/kinking in 11 (39%) of the patients. Stent compression and recoil, not intimal hyperplasia, were the major contributing factors to restenosis.<br />Conclusion: Compared to the restenosis rate of bare metal stents reported in the literature, DES seems to be superior for the treatment of VAOS. However, stent compression and recoil are relevant problems contributing to restenosis. Further improvement of the materials for the interventional treatment of VAOS seems necessary.
- Subjects :
- Aged
Cohort Studies
Female
Graft Occlusion, Vascular diagnosis
Graft Occlusion, Vascular epidemiology
Graft Occlusion, Vascular prevention & control
Humans
Male
Paclitaxel administration & dosage
Retrospective Studies
Stroke diagnosis
Stroke epidemiology
Stroke prevention & control
Treatment Outcome
Tubulin Modulators administration & dosage
Vertebrobasilar Insufficiency complications
Vertebrobasilar Insufficiency diagnosis
Angioplasty
Drug-Eluting Stents
Vertebrobasilar Insufficiency therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1545-1550
- Volume :
- 17
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists
- Publication Type :
- Academic Journal
- Accession number :
- 20426646
- Full Text :
- https://doi.org/10.1583/09-2904.1