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Recent insights in pre-mRNA 3'-end processing signals and proteins in the protozoan parasite Entamoeba histolytica.
- Source :
-
Infectious disorders drug targets [Infect Disord Drug Targets] 2010 Aug; Vol. 10 (4), pp. 258-65. - Publication Year :
- 2010
-
Abstract
- The messenger RNA precursors (pre-mRNA) 3'-end processing occurs in a two-step co-transcriptional coupled reaction, denoted as cleavage and polyadenylation. Both processes depend on trans-acting factors interacting in a coordinated manner with cis-sequence motifs located at the 3' untranslated region of transcripts. In this paper, we reviewed mechanisms involved in pre-mRNA processing in eukaryotic organisms, including our own findings about sequences and proteins potentially involved in mRNA 3'-end formation in the protozoan parasite Entamoeba histolytica. Interestingly, protein sequence comparisons among E. histolytica, yeast, and human pre-mRNA processing machineries showed that amoeba pre-mRNA 3'-end processing machinery appears to be in an intermediate evolutionary position between mammals and yeast. In addition, the presence of non canonical poly(A) polymerases family recently identified in E. histolytica, adds more complexity to the mRNA 3'-end formation process in this ancient eukaryote.
- Subjects :
- 3' Untranslated Regions
Entamoeba histolytica pathogenicity
Entamoebiasis parasitology
Genome, Protozoan
Humans
Models, Biological
Polynucleotide Adenylyltransferase chemistry
Polynucleotide Adenylyltransferase genetics
Polynucleotide Adenylyltransferase metabolism
Protozoan Proteins genetics
Protozoan Proteins metabolism
RNA Processing, Post-Transcriptional
Saccharomyces cerevisiae genetics
Saccharomyces cerevisiae metabolism
Species Specificity
mRNA Cleavage and Polyadenylation Factors genetics
mRNA Cleavage and Polyadenylation Factors metabolism
Entamoeba histolytica genetics
Entamoeba histolytica metabolism
RNA Precursors genetics
RNA Precursors metabolism
RNA, Protozoan genetics
RNA, Protozoan metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2212-3989
- Volume :
- 10
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Infectious disorders drug targets
- Publication Type :
- Academic Journal
- Accession number :
- 20429864
- Full Text :
- https://doi.org/10.2174/187152610791591575