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[Effect of proteins extracted from mycelia of Omphalia lapidescens on inhibiting H, liver cancer in mice and regulating immune function].
- Source :
-
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials [Zhong Yao Cai] 2009 Dec; Vol. 32 (12), pp. 1870-4. - Publication Year :
- 2009
-
Abstract
- Objective: To explore the effect of proteins extraceed from mycelia of Omphalia lapidescens on inhibiting H22 liver cancer in vivo.<br />Methods: 50 hepatoma 22 tumor bearing mice models were divided into five groups randomly:control group( CG), cyclophosphamide group, and 3 groups of incremental Hepatoma 22 dosages (5, 3, 1 mg/kg). All groups were i.v. with drugs once a day. After 8 consecutive days, the concentrations of interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) in serum were detected by enzyme-linked immunoabsorbent assay (ELISA). The weight changes of tumor, thymus, liver, heart, spleen, lung and kidney were observed.<br />Results: It showed the tumors' weight were significant heavier in CG than in EGs. The tumor-inhibition rate (IR) was 36.4% in high dosage group,which was lower than 43.2% in cyclophosphamide group. The spleen mass of proteins groups increased significantly. The concentration of IFN-gamma in serum of proteins groups increased as CG, but IL-4 in inverse direction. The observations of thymus, liver, heart, lung and kidney in EGs were the same as CG.<br />Conclusion: The proteins extracted from mycelium of Omphalia lapidescens can inhibit the growth of tumour and enhance the immune function of H22 tumor-bearing mice.
- Subjects :
- Animals
Antineoplastic Agents administration & dosage
Antineoplastic Agents pharmacology
Cyclophosphamide pharmacology
Cyclophosphamide therapeutic use
Drugs, Chinese Herbal administration & dosage
Drugs, Chinese Herbal pharmacology
Interferon-gamma blood
Interleukin-2 blood
Liver drug effects
Liver pathology
Liver Neoplasms, Experimental blood
Male
Mice
Mice, Inbred ICR
Phytotherapy
Random Allocation
Spleen drug effects
Spleen immunology
Thymus Gland drug effects
Thymus Gland immunology
Antineoplastic Agents therapeutic use
Cell Proliferation drug effects
Drugs, Chinese Herbal therapeutic use
Liver Neoplasms, Experimental drug therapy
Polyporaceae chemistry
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1001-4454
- Volume :
- 32
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
- Publication Type :
- Academic Journal
- Accession number :
- 20432906