Explosive HIV-1 subtype B' epidemics in Asia driven by geographic and risk group founder events.

Authors :: Li Y
Uenishi R
Hase S
Liao H
Li XJ
Tsuchiura T
Tee KK
Pybus OG
Takebe Y
Source :: Virology [Virology] 2010 Jul 05; Vol. 402 (2), pp. 223-7. Date of Electronic Publication: 2010 May 01.
Publication Year :: 2010
Abstract: We explored the timescale, spatial spread, and risk group population structure of HIV-1 subtype B', the cause of explosive blood-borne HIV-1 epidemics among injecting drug users (IDUs) and former plasma donors (FPDs) in Asia. Sequences from FPDs in China formed a distinct monophyletic cluster within subtype B'. Further analysis revealed that subtype B' was founded by a single lineage of pandemic subtype B around 1985. Subsequently, the FPD cluster appears to have derived from a single subtype B' lineage around 1991, corroborating the hypothesis that FPD outbreaks stemmed from the preceding epidemic among IDUs in Southeast Asia, most likely from the Golden-Triangle region.<br /> (Copyright 2010 Elsevier Inc. All rights reserved.)

Full Text Access

Tools