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Consensus statement: minimal criteria for reporting the systemic inflammatory response to cardiopulmonary bypass.

Authors :
Clive Landis R
Murkin JM
Stump DA
Baker RA
Arrowsmith JE
De Somer F
Dain SL
Dobkowski WB
Ellis JE
Falter F
Fischer G
Hammon JW
Jonas RA
Kramer RS
Likosky DS
Paget Milsom F
Poullis M
Verrier ED
Walley K
Westaby S
Source :
The heart surgery forum [Heart Surg Forum] 2010 Apr; Vol. 13 (2), pp. E116-23.
Publication Year :
2010

Abstract

The lack of established cause and effect between putative mediators of inflammation and adverse clinical outcomes has been responsible for many failed anti-inflammatory interventions in cardiopulmonary bypass (CPB). Candidate interventions that impress in preclinical trials by suppressing a given inflammation marker might fail at the clinical trial stage because the marker of interest is not linked causally to an adverse outcome. Alternatively, there exist examples in which pharmaceutical agents or other interventions improve clinical outcomes but for which we are uncertain of any antiinflammatory mechanism. The Outcomes consensus panel made 3 recommendations in 2009 for the conduct of clinical trials focused on the systemic inflammatory response. This panel was tasked with updating, as well as simplifying, a previous consensus statement. The present recommendations for investigators are the following: (1) Measure at least 1 inflammation marker, defined in broad terms; (2) measure at least 1clinical end point, drawn from a list of practical yet clinically meaningful end points suggested by the consensus panel; and(3) report a core set of CPB and perfusion criteria that maybe linked to outcomes. Our collective belief is that adhering to these simple consensus recommendations will help define the influence of CPB practice on the systemic inflammatory response, advance our understanding of causal inflammatory mechanisms, and standardize the reporting of research findings in the peer-reviewed literature.

Details

Language :
English
ISSN :
1522-6662
Volume :
13
Issue :
2
Database :
MEDLINE
Journal :
The heart surgery forum
Publication Type :
Academic Journal
Accession number :
20444674
Full Text :
https://doi.org/10.1532/HSF98.20101022