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[Effects of jingqianshu granule on expression of estrogen receptor alpha and beta mRNA in hypothalamus and hippocampus of PMS rats with liver-qi depression].
- Source :
-
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2010 Feb; Vol. 35 (4), pp. 489-92. - Publication Year :
- 2010
-
Abstract
- Objective: To investigate the effects of Jingqianshu granule (JQS), a Chinese medicinal formula on the expression levels of ERa and ERbeta mRNA in hypothalamus and hippocampus of PMS model rats with liver-qi depression.<br />Method: The female SD rats were divided randomly into three groups: control, model and model plus Jingqianshu granule. We make the model rats of PMS with liver-qi depression using the method of emotional stimulation multiple factors. Then we applied semi-quantitative RT-PCR gene amplification technology to detect the expression levels of ERalpha and ERbeta mRNA in the brain regions of all rats.<br />Result: Compared with the control group, the expression levels of ERalpha and ERbeta mRNA in hypothalamus and hippocampus of model rats were higher significantly (P < 0.05), while in the JQS-administration group, the expression levels of ERalpha and ERbeta mRNA were lower than model group (P < 0.05), and were no difference with the control group.<br />Conclusion: The JQS granule can down-regulate the expression levels of ERalpha and ERbeta mRNA in hypothalamus and hippocampus, which maybe one of the mechanism to treat PMS with Liver-qi depression.
- Subjects :
- Animals
Disease Models, Animal
Dosage Forms
Female
Hippocampus metabolism
Humans
Hypothalamus metabolism
Liver drug effects
Premenstrual Syndrome genetics
Premenstrual Syndrome metabolism
Random Allocation
Rats
Rats, Sprague-Dawley
Receptors, Estrogen metabolism
Drugs, Chinese Herbal administration & dosage
Gene Expression drug effects
Hippocampus drug effects
Hypothalamus drug effects
Liver physiology
Premenstrual Syndrome drug therapy
Qi
Receptors, Estrogen genetics
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1001-5302
- Volume :
- 35
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
- Publication Type :
- Academic Journal
- Accession number :
- 20450050
- Full Text :
- https://doi.org/10.4268/cjcmm20100418